The concentrations of Al, Ba, Ca, Co, Cr, Cu, Fe, Mg, Mn, Ni, Pb, Sr and Zn in the human hair of dependence drug addicts and healthy contrast were determined by ICP-AES. The RSD of the method was 1.3%-4.9%, and recovery was 89%-129%. Correlation of the trace elements was analyzed by SPSS software. The contents of Zn and Ca in the hair of dependence drug addicts were lower, while those of Pb, Fe and Mg were higher than healthy contrasts. The result provided a foundation for improving immune function of dependence drug addicts and enhancing the effect of giving up taking addictive drugs.