Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality

Psychiatry Res. 2005 Apr 15;134(2):195-8. doi: 10.1016/j.psychres.2005.01.005.

Abstract

Allele and haplotype frequencies of a promoter polymorphism in the gene encoding tryptophan hydroxylase (TPH2) did not differ in 83 suicidal schizophrenic patients compared with 170 non-suicidal schizophrenic patients. These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Chi-Square Distribution
  • Chromosomes, Human, Pair 11 / genetics
  • Female
  • Genetic Markers
  • Haplotypes / genetics
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Protein Isoforms / genetics
  • Schizophrenia* / enzymology
  • Schizophrenia* / epidemiology
  • Schizophrenia* / genetics
  • Suicide, Attempted / statistics & numerical data*
  • Tryptophan Hydroxylase / genetics*
  • Tryptophan Hydroxylase / metabolism*

Substances

  • Genetic Markers
  • Protein Isoforms
  • TPH2 protein, human
  • Tryptophan Hydroxylase