SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: a molecular epidemiologic case-control study

Cancer Res. 2005 Apr 15;65(8):3049-52. doi: 10.1158/0008-5472.CAN-04-2219.

Abstract

We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Asbestos / poisoning*
  • Case-Control Studies
  • Cocarcinogenesis*
  • DNA, Neoplasm / genetics
  • Female
  • Humans
  • Male
  • Mesothelioma / epidemiology
  • Mesothelioma / etiology*
  • Mesothelioma / genetics
  • Mesothelioma / virology
  • Molecular Epidemiology
  • Polymerase Chain Reaction
  • Polyomavirus Infections / complications*
  • Polyomavirus Infections / virology
  • Simian virus 40 / genetics
  • Simian virus 40 / physiology*
  • Tumor Virus Infections / complications*
  • Tumor Virus Infections / virology
  • Urinary Bladder Neoplasms / epidemiology
  • Urinary Bladder Neoplasms / etiology
  • Urinary Bladder Neoplasms / genetics
  • Urinary Bladder Neoplasms / virology

Substances

  • DNA, Neoplasm
  • Asbestos