Abstract
We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was detected. These results indicate that KD has neuroprotective effects throughout diminishing nuclear clusterin accumulation that is involved in caspase-3 independent cell death mechanism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animal Nutritional Physiological Phenomena
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Animals
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Apoptosis / physiology*
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Cell Death / physiology
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Clusterin
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Dietary Carbohydrates / metabolism
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Dietary Fats / metabolism
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Disease Models, Animal
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Glycoproteins / metabolism*
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Hippocampus / metabolism*
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Kainic Acid
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Ketone Bodies / metabolism
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Ketosis / metabolism*
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Male
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Mice
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Mice, Inbred ICR
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Molecular Chaperones / metabolism*
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Seizures / chemically induced
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Seizures / metabolism*
Substances
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Clu protein, mouse
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Clusterin
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Dietary Carbohydrates
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Dietary Fats
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Glycoproteins
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Ketone Bodies
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Molecular Chaperones
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Kainic Acid