Siting wells near streams requires an accurate estimate of the quantity of water derived from the river due to pumping. A number of hydrogeological and hydraulic parameters influence this value. This study estimates stream depletion under steady-state conditions for a variety of hydrogeological systems. A finite differences model was used to analyze several hydrogeological situations, and for each of these the stream depletion was estimated using an advective transport method. An empirical equation for stream depletion was obtained for the case of a stream that partially penetrates the aquifer and a pumping well that is screened over a portion of the aquifer. The derived equation, which is valid for both isotropic and anisotropic conditions, expresses stream depletion as a function of the unit inflow to the river, the discharge of the pumping well, the well screen length, the distance between the river and pumping well, the wetted perimeter, and a new parameter called "overlap," which is defined to be the distance between the riverbed and the top of well screen. The overlap parameter makes it possible to consider indirectly the vertical component of flow, which is accentuated when the well is screened below the streambed. The formula proposed here should be useful in deciding where to locate a pumping well and to decide the appropriate length of its screen.