Thermosensitive biodegradable polydepsipeptide

Macromol Biosci. 2005 Apr 19;5(4):273-6. doi: 10.1002/mabi.200400221.

Abstract

A poly(N-isopropylacrylamide) (PNIPAAm)-like biodegradable thermosensitive polydepsipeptide, poly[Glc-Asn(N-isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc-Asn]. Poly[Glc-Asn(N-isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non-toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 degrees C in water, make this polymer attractive for biomedical implant applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / metabolism*
  • Biocompatible Materials / toxicity
  • Biodegradation, Environmental
  • Cell Survival
  • Cells, Cultured
  • Depsipeptides / chemical synthesis
  • Depsipeptides / metabolism*
  • Depsipeptides / toxicity
  • Fibroblasts / drug effects
  • Mice
  • Peptides / chemical synthesis
  • Peptides / metabolism
  • Peptides / toxicity
  • Temperature*

Substances

  • Biocompatible Materials
  • Depsipeptides
  • Peptides
  • poly(glycolic acid-co-N-isopropylasparagine)