Abstract
A poly(N-isopropylacrylamide) (PNIPAAm)-like biodegradable thermosensitive polydepsipeptide, poly[Glc-Asn(N-isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc-Asn]. Poly[Glc-Asn(N-isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non-toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 degrees C in water, make this polymer attractive for biomedical implant applications.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / metabolism*
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Biocompatible Materials / toxicity
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Biodegradation, Environmental
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Cell Survival
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Cells, Cultured
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Depsipeptides / chemical synthesis
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Depsipeptides / metabolism*
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Depsipeptides / toxicity
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Fibroblasts / drug effects
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Mice
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Peptides / chemical synthesis
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Peptides / metabolism
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Peptides / toxicity
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Temperature*
Substances
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Biocompatible Materials
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Depsipeptides
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Peptides
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poly(glycolic acid-co-N-isopropylasparagine)