Abstract
Topoisomerase II inhibitors represent a broad class of antineoplastic agents with a wide spectrum of activity against malignancies. Topoisomerase II inhibitors include the anthracyclines, mitoxantrone and epipodophyllotoxins. Short-term toxicity includes myelosuppression and gastrointestinal toxicity. Long-term survivors are at risk of cardiac toxicity and secondary leukaemia. This article discusses these toxicities in detail, including administration of these agents to patients with hepatic and/or renal insufficiency, and the need for dose adjustments in selected patient populations.
MeSH terms
-
Antineoplastic Agents / adverse effects*
-
Antineoplastic Agents / pharmacokinetics
-
Cardiovascular Diseases / chemically induced
-
Daunorubicin / adverse effects
-
Doxorubicin / adverse effects
-
Enzyme Inhibitors / adverse effects*
-
Enzyme Inhibitors / pharmacokinetics
-
Epirubicin / adverse effects
-
Etoposide / adverse effects
-
Humans
-
Idarubicin / adverse effects
-
Leukemia / chemically induced
-
Middle Aged
-
Mitoxantrone / adverse effects
-
Mucositis / chemically induced
-
Podophyllotoxin / adverse effects
-
Teniposide / adverse effects
-
Topoisomerase II Inhibitors*
-
Vascular Diseases / chemically induced
Substances
-
Antineoplastic Agents
-
Enzyme Inhibitors
-
Topoisomerase II Inhibitors
-
Epirubicin
-
Etoposide
-
Doxorubicin
-
Teniposide
-
Mitoxantrone
-
Podophyllotoxin
-
Idarubicin
-
Daunorubicin