CTX-M-10 linked to a phage-related element is widely disseminated among Enterobacteriaceae in a Spanish hospital

Antimicrob Agents Chemother. 2005 Apr;49(4):1567-71. doi: 10.1128/AAC.49.4.1567-1571.2005.

Abstract

CTX-M-10 has been widely disseminated among multiple clones of several species of Enterobacteriaceae, harboring seemingly different plasmids, for over a decade in Ramón y Cajal University Hospital, Madrid, Spain. Cloning and sequencing of a 12.2-kb DNA fragment from plasmid pRYCE21 from Klebsiella pneumoniae strain KP4aC revealed a novel phage-related element immediately upstream of bla(CTX-M-10) conserved among different CTX-M-10-producing strains. This is the first report showing an extended-spectrum-beta-lactamase gene linked to a phage-related element.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacteriophages / genetics*
  • Enterobacteriaceae / classification
  • Enterobacteriaceae / enzymology
  • Enterobacteriaceae / genetics
  • Enterobacteriaceae Infections / microbiology
  • Hospitals
  • Humans
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / virology
  • Molecular Sequence Data
  • Plasmids / genetics
  • Sequence Analysis, DNA
  • Spain
  • beta-Lactamases / genetics*

Substances

  • beta-Lactamases

Associated data

  • GENBANK/AY598759