beta-Hematin (hemozoin) mediated decompostion of polyunsaturated fatty acids to 4-hydroxy-2-nonenal

Inorg Chem. 2005 Apr 4;44(7):2134-6. doi: 10.1021/ic048821i.

Abstract

beta-Hematin is an important heme metabolite of malarial infection. Its role as an agent mediating the formation of the reactive electrophile 4-hydroxynonenal (HNE) from polyunsaturated fatty acids was investigated. In vitro formation of HNE was found to be facilitated by the presence of hemozoin in a concentration-dependent fashion. The reactivity of HNE derived from reaction with beta-hematin was confirmed through its ability to form protein adducts on myoglobin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aldehydes / metabolism*
  • Animals
  • Fatty Acids, Unsaturated / metabolism*
  • Heme / metabolism*
  • Hemeproteins / analysis*
  • Hemeproteins / biosynthesis
  • Malaria / metabolism
  • Myoglobin / chemistry
  • Plasmodium falciparum / metabolism*

Substances

  • Aldehydes
  • Fatty Acids, Unsaturated
  • Hemeproteins
  • Myoglobin
  • hemozoin
  • Heme
  • 4-hydroxy-2-nonenal