Abstract
The dried roots of Ferula hermonis yielded three new daucanes, (1R,4R)-4-hydroxydauca-7-ene-6-one (1), (1R,4R)-4-hydroxydauca-7-ene-6,9-dione (2), and (1R,3S,8S)-3-ethoxy-8-angeloyloxydauca-4-en-9-one (3), together with the three known sesquiterpenes, ferutinin, teferidin, and (+)-alpha-bisabolol. The structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence. The effect of these compounds on the proliferation of estrogen-dependent MCF-7 cells was evaluated, and it was found that compounds 1 and 3 exhibited proliferative activity, whereas 2 showed an antiproliferative effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzoates / chemistry
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Benzoates / isolation & purification
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Bridged Bicyclo Compounds
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Cycloheptanes
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Drug Screening Assays, Antitumor
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Estrogens / chemistry
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Estrogens / isolation & purification*
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Estrogens / pharmacology
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Ferula / chemistry*
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Lebanon
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Molecular Structure
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Monocyclic Sesquiterpenes
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Benzoates
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Bridged Bicyclo Compounds
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Cycloheptanes
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Estrogens
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Monocyclic Sesquiterpenes
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Sesquiterpenes
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bisabolol
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4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en