Cerylimycins [corrected] A and B: antibacterial triterpenes from the new species Tricholoma sp. AU1

Simon P B Ovenden; Jin Yu; Jill Bernays; Soo San Wan; Larissa J Christophidis; Gian Sberna; R Murray Tait; Howard G Wildman; Dominique Lebeller; Denis Platel; Tom W May; Barbara M Meurer-Grimes

doi:10.1021/np049747j

Cerylimycins [corrected] A and B: antibacterial triterpenes from the new species Tricholoma sp. AU1

J Nat Prod. 2005 Mar;68(3):409-12. doi: 10.1021/np049747j.

Authors

Simon P B Ovenden¹, Jin Yu, Jill Bernays, Soo San Wan, Larissa J Christophidis, Gian Sberna, R Murray Tait, Howard G Wildman, Dominique Lebeller, Denis Platel, Tom W May, Barbara M Meurer-Grimes

Affiliation

¹ Cerylid Biosciences, 576 Swan Street Richmond, Victoria, 3121, Australia.

PMID: 15787446
DOI: 10.1021/np049747j

Abstract

To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemistry of 1 and 2 were determined through extensive 2D NMR spectroscopy, while the inhibitory activity of 1 and 2 against two Gram-positive and two Gram-negative bacteria and a mammalian cell line was determined.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Australia
Basidiomycota / chemistry*
Drug Screening Assays, Antitumor
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Humans
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology
Tumor Cells, Cultured

Substances

Anti-Bacterial Agents
Triterpenes
trichomycin B
trichomycin A