Can we get more HIV-positive tuberculosis patients on antiretroviral treatment in a rural district of Malawi?

Int J Tuberc Lung Dis. 2005 Mar;9(3):238-47.

Abstract

The World Health Organization (WHO) has set a target of treating 3 million people with antiretroviral treatment (ART) by 2005. In sub-Saharan Africa, HIV-positive tuberculosis (TB) patients could significantly contribute to this target. ART (stavudine/lamivudine/nevirapine) was initiated in Thyolo district, Malawi, in April 2003, and all HIV-positive TB patients were considered eligible and offered ART. Despite this, only 44 (13%) of 352 TB patients were eventually started on ART by the end of November 2003. Most TB patients leave hospital after 2 weeks to complete the initial phase of anti-tuberculosis treatment (rifampicin-based) in the community, and ART is offered to HIV-positive TB patients after they have started the continuation phase of treatment (isoniazid/ ethambutol). ART is only offered at hospital, while the majority of TB patients take their continuation phase of anti-tuberculosis treatment from health centres. HIV-positive TB patients therefore find it difficult to access ART. In this paper, we discuss a series of options to increase the uptake of ART among HIV-positive TB patients. The main options are: 1) to hospitalise HIV-positive TB patients with a view to starting ART in the continuation phase in hospital; 2) to decentralise ART delivery so ART can be delivered at health centres; 3) to replace nevirapine with efavirenz so ART can be started earlier in the initial phase of anti-tuberculosis treatment. Decentralisation of ART from hospitals to health centres would greatly improve ART access.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active / methods
  • Antitubercular Agents / therapeutic use
  • Drug Therapy, Combination
  • Drug Utilization
  • HIV Seropositivity / complications
  • HIV Seropositivity / drug therapy*
  • HIV Seropositivity / epidemiology
  • Humans
  • Lamivudine / therapeutic use
  • Malawi / epidemiology
  • National Health Programs / trends
  • Nevirapine / therapeutic use
  • Prevalence
  • Rural Population*
  • Stavudine / therapeutic use
  • Tuberculosis / complications
  • Tuberculosis / drug therapy*
  • Tuberculosis / epidemiology
  • World Health Organization

Substances

  • Anti-HIV Agents
  • Antitubercular Agents
  • Lamivudine
  • Nevirapine
  • Stavudine