Abstract
The chemokine response of eight children with serologically confirmed severe acute respiratory syndrome (SARS) was longitudinally monitored. All had raised plasma interferon gamma inducible protein (IP-10) concentrations, which suggested an active type 1 T-helper lymphocyte mediated immune response. High circulating IP-10 levels could facilitate viral clearance and might play a role in assisting the recovery of the patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chemokine CCL2 / metabolism
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Chemokine CCL5 / metabolism
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Chemokine CXCL10
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Chemokine CXCL9
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Chemokines / metabolism*
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Chemokines, CXC / metabolism
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Child
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Humans
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Intercellular Signaling Peptides and Proteins / metabolism
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Interferon-gamma / metabolism
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Longitudinal Studies
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Severe Acute Respiratory Syndrome / blood*
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T-Lymphocytes / metabolism
Substances
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CCL2 protein, human
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CXCL10 protein, human
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CXCL9 protein, human
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Chemokine CCL2
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Chemokine CCL5
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Chemokine CXCL10
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Chemokine CXCL9
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Chemokines
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Chemokines, CXC
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Intercellular Signaling Peptides and Proteins
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Interferon-gamma