Chemokine response in children with SARS

Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.

Abstract

The chemokine response of eight children with serologically confirmed severe acute respiratory syndrome (SARS) was longitudinally monitored. All had raised plasma interferon gamma inducible protein (IP-10) concentrations, which suggested an active type 1 T-helper lymphocyte mediated immune response. High circulating IP-10 levels could facilitate viral clearance and might play a role in assisting the recovery of the patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemokine CCL2 / metabolism
  • Chemokine CCL5 / metabolism
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Chemokines / metabolism*
  • Chemokines, CXC / metabolism
  • Child
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Interferon-gamma / metabolism
  • Longitudinal Studies
  • Severe Acute Respiratory Syndrome / blood*
  • T-Lymphocytes / metabolism

Substances

  • CCL2 protein, human
  • CXCL10 protein, human
  • CXCL9 protein, human
  • Chemokine CCL2
  • Chemokine CCL5
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Chemokines
  • Chemokines, CXC
  • Intercellular Signaling Peptides and Proteins
  • Interferon-gamma