Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities

Junsong Wang; Yongtang Zheng; Thomas Efferth; Ruirui Wang; Yuemao Shen; Xiaojiang Hao

doi:10.1016/j.phytochem.2005.02.003

Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities

Phytochemistry. 2005 Mar;66(6):697-701. doi: 10.1016/j.phytochem.2005.02.003.

Authors

Junsong Wang¹, Yongtang Zheng, Thomas Efferth, Ruirui Wang, Yuemao Shen, Xiaojiang Hao

Affiliation

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongton, Kunming, Yunnan 650204, PR China.

PMID: 15771893
DOI: 10.1016/j.phytochem.2005.02.003

Abstract

A diprenylated indole, (E)-3-(3-hydroxymethyl-2-butenyl)-7-(3-methyl-2-butenyl)-1H-indole (1), and six known carbazole alkaloids were isolated from the twigs and leaves of Glycosmis montana Pierre (Rutaceae). Their structures were determined on the basis of analysis of spectral evidence including 1D and 2D NMR and MS. The alkaloids (1-3) exhibited weak to moderate take in vitro inhibitory activity against HIV replication in C8166 cells, and they (as well as carbalexine A and B) had cytotoxic activity against the human leukaemia cell line CCRF-CEM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / isolation & purification
Anti-HIV Agents / pharmacology*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Carbazoles / chemistry*
Carbazoles / isolation & purification
Carbazoles / pharmacology
Cell Line
Cell Line, Tumor
HIV-1 / drug effects
Humans
Indoles / chemistry*
Indoles / isolation & purification
Indoles / pharmacology
Inhibitory Concentration 50
Leukemia / drug therapy
Molecular Structure
Plant Components, Aerial / chemistry
Rutaceae / chemistry*

Substances

Anti-HIV Agents
Antineoplastic Agents, Phytogenic
Carbazoles
Indoles