Abstract
The causes of target cell death in organ-specific autoimmune diseases are not precisely known. In the case of EAG, parietal cell death depends on Th1 CD4 T cells and Fas/Fas-ligand, either through interaction between infiltrating CD4 T cells with gastric parietal cells that have upregulated Fas expression or through homotypic interactions between the parietal cells. TNF-alpha does not appear to have a role in this process. The accompanying loss of zymogenic cells is likely a consequence of the interruption of the normal developmental pathway in the gastric mucosa that follows the destruction of parietal cells in the gastric mucosa.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis*
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Autoimmune Diseases / immunology*
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Autoimmune Diseases / pathology
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CD4-Positive T-Lymphocytes / immunology
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Cytokines / physiology
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Fas Ligand Protein
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Gastritis / immunology*
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Gastritis / pathology
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Humans
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Membrane Glycoproteins / physiology*
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Mice
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Parietal Cells, Gastric / immunology*
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Parietal Cells, Gastric / pathology*
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Receptors, Tumor Necrosis Factor / physiology
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Signal Transduction
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Th1 Cells / immunology
Substances
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Cytokines
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FASLG protein, human
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Fas Ligand Protein
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Fasl protein, mouse
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Membrane Glycoproteins
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Receptors, Tumor Necrosis Factor