Methotrexate in resistant ENL

Int J Lepr Other Mycobact Dis. 2004 Dec;72(4):480-2. doi: 10.1489/1544-581X(2004)72<480:MIRE>2.0.CO;2.

Abstract

This is a report of a case of steroid resistant severe Type 2 reaction that was managed with methotrexate and prednisolone. Synergistic action of both the drugs in severe Type 2 reaction make them one of the preferred combinations in the absence of other agents such as thalidomide.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Anti-Inflammatory Agents / therapeutic use
  • Drug Synergism
  • Erythema Nodosum / drug therapy*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Leprosy, Lepromatous / drug therapy*
  • Male
  • Methotrexate / therapeutic use*
  • Middle Aged
  • Prednisolone / therapeutic use
  • Treatment Failure
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Immunosuppressive Agents
  • Prednisolone
  • Methotrexate