The effect of am 251, a cannabinoid CB1 receptor antagonist, on food intake in rats

Acta Pol Pharm. 2004 Sep-Oct;61(5):401-3.

Abstract

The anorectic effect of AM 251 (N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-di-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide), a CB1 receptor antagonist, was studied in rats. AM 251 (0.5-2.0 mg/kg i.p.) significantly and dose-dependently reduced food intake in both free-feeding and food-deprived rats. The obtained results support the anorectic activity of CB1 receptors antagonists.

MeSH terms

  • Animals
  • Anti-Obesity Agents / administration & dosage
  • Anti-Obesity Agents / pharmacology*
  • Dose-Response Relationship, Drug
  • Exploratory Behavior / drug effects
  • Feeding Behavior / drug effects*
  • Food Deprivation
  • Male
  • Piperidines / administration & dosage
  • Piperidines / pharmacology*
  • Pyrazoles / administration & dosage
  • Pyrazoles / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptor, Cannabinoid, CB1 / antagonists & inhibitors*

Substances

  • Anti-Obesity Agents
  • Piperidines
  • Pyrazoles
  • Receptor, Cannabinoid, CB1
  • AM 251