Abstract
The anorectic effect of AM 251 (N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-di-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide), a CB1 receptor antagonist, was studied in rats. AM 251 (0.5-2.0 mg/kg i.p.) significantly and dose-dependently reduced food intake in both free-feeding and food-deprived rats. The obtained results support the anorectic activity of CB1 receptors antagonists.
MeSH terms
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Animals
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Anti-Obesity Agents / administration & dosage
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Anti-Obesity Agents / pharmacology*
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Dose-Response Relationship, Drug
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Exploratory Behavior / drug effects
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Feeding Behavior / drug effects*
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Food Deprivation
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Male
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Piperidines / administration & dosage
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Piperidines / pharmacology*
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Pyrazoles / administration & dosage
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Pyrazoles / pharmacology*
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Rats
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Rats, Wistar
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Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
Substances
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Anti-Obesity Agents
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Piperidines
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Pyrazoles
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Receptor, Cannabinoid, CB1
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AM 251