Abstract
The phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded five new aromatic compounds (1-5), of which the bruguierols A - C (1-3) represent a new structural skeleton in natural product chemistry. All structures have been determined by NMR spectroscopic studies. Among them, 3 showed moderate activity against Gram-positive and Gram-negative bacteria including mycobacteria and resistant strains (MICs 12.5 microg/mL).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Drug Resistance, Bacterial
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Heterocyclic Compounds, 3-Ring / administration & dosage
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Heterocyclic Compounds, 3-Ring / pharmacology*
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Heterocyclic Compounds, 3-Ring / therapeutic use
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Humans
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Microbial Sensitivity Tests
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Stems
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Rhizophoraceae*
Substances
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Anti-Bacterial Agents
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Heterocyclic Compounds, 3-Ring
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Plant Extracts
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bruguierol A