VDUP1 is required for the development of natural killer cells

Immunity. 2005 Feb;22(2):195-208. doi: 10.1016/j.immuni.2004.12.012.

Abstract

Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Carrier Proteins / genetics
  • Carrier Proteins / immunology
  • Carrier Proteins / metabolism*
  • Cell Differentiation*
  • Cell Line
  • Gene Deletion
  • Gene Expression Regulation
  • Humans
  • Hyperplasia / metabolism
  • Hyperplasia / pathology
  • Killer Cells, Natural / cytology
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / metabolism*
  • Mice
  • Mice, Knockout
  • Neoplasm Transplantation
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Receptors, Interleukin-2 / metabolism
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Thioredoxins / genetics
  • Thioredoxins / immunology
  • Thioredoxins / metabolism*

Substances

  • Carrier Proteins
  • Receptors, Interleukin-2
  • Txnip protein, mouse
  • Thioredoxins