A new pinoresinol-type lignan from Ligularia kanaitizensis

Nat Prod Res. 2005 Feb;19(2):125-9. doi: 10.1080/14786410410001704723.

Abstract

A new pinoresinol-type Lignan, 9alpha-angloyloxypinoresinol (1), was isolated from the roots and rhizomes of Ligularia kanaitizensis (Franch.) Hand.-Mazz, in addition to a known compound, 9alpha-hydroxypinoresinol (2). The structure of this new lignan (1) was established on the basis of 1D and 2D NMR experiments. Anti-HIV-1 RT biological assay showed that 1 was inhibitory to HIV-1 RT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asteraceae / chemistry*
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • HIV Reverse Transcriptase / antagonists & inhibitors
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • Magnetic Resonance Spectroscopy

Substances

  • 9alpha-angloyloxypinoresinol
  • Furans
  • Lignans
  • HIV Reverse Transcriptase