Abstract
A new pinoresinol-type Lignan, 9alpha-angloyloxypinoresinol (1), was isolated from the roots and rhizomes of Ligularia kanaitizensis (Franch.) Hand.-Mazz, in addition to a known compound, 9alpha-hydroxypinoresinol (2). The structure of this new lignan (1) was established on the basis of 1D and 2D NMR experiments. Anti-HIV-1 RT biological assay showed that 1 was inhibitory to HIV-1 RT.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Asteraceae / chemistry*
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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HIV Reverse Transcriptase / antagonists & inhibitors
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Magnetic Resonance Spectroscopy
Substances
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9alpha-angloyloxypinoresinol
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Furans
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Lignans
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HIV Reverse Transcriptase