Abstract
The Twisted gastrulation (Tsg) proteins are modulators of bone morphogenetic protein (BMP) activity in both vertebrates and insects. We find that the crossveinless (cv) gene of Drosophila encodes a new tsg-like gene. Genetic experiments show that cv, similarly to tsg, interacts with short gastrulation (sog) to modulate BMP signalling. Despite this common property, Cv shows a different BMP ligand specificity as compared with Tsg, and its expression is limited to the developing wing. These findings and the presence of two types of Tsg-like protein in several insects suggest that Cv represents a subgroup of the Tsg-like BMP-modulating proteins.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Amino Acid Sequence
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Animals
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Bone Morphogenetic Proteins / genetics
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Bone Morphogenetic Proteins / metabolism*
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Diffusion
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Drosophila Proteins / chemistry
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Drosophila Proteins / classification*
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Drosophila melanogaster / genetics
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Drosophila melanogaster / growth & development
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Drosophila melanogaster / metabolism*
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Female
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Gene Expression Regulation, Developmental
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Genomics
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Ligands
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Male
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Molecular Sequence Data
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Sequence Alignment
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Sequence Deletion / genetics
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Signal Transduction*
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Substrate Specificity
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Wings, Animal / growth & development
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Wings, Animal / metabolism
Substances
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Bone Morphogenetic Proteins
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Drosophila Proteins
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Ligands
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TSG protein, Drosophila
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sog protein, Drosophila