Molecular insights into aminoglycoside action and resistance

Chem Rev. 2005 Feb;105(2):477-98. doi: 10.1021/cr0301088.

Authors

Sophie Magnet¹, John S Blanchard

Affiliation

¹ Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

PMID: 15700953
DOI: 10.1021/cr0301088

No abstract available

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Aminoglycosides* / chemistry
Aminoglycosides* / metabolism
Aminoglycosides* / pharmacology
Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / metabolism
Anti-Bacterial Agents* / pharmacology
Binding Sites
Drug Resistance, Bacterial / genetics
Drug Resistance, Bacterial / physiology*
Gram-Negative Bacteria / drug effects*
Gram-Negative Bacteria / genetics
Gram-Negative Bacteria / physiology
Gram-Negative Bacterial Infections / drug therapy
Humans
Molecular Structure
RNA, Bacterial / genetics
RNA, Bacterial / metabolism
RNA, Ribosomal, 16S / genetics
RNA, Ribosomal, 16S / metabolism*
Structure-Activity Relationship

Substances

Aminoglycosides
Anti-Bacterial Agents
RNA, Bacterial
RNA, Ribosomal, 16S