High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania

J Clin Microbiol. 2005 Feb;43(2):745-9. doi: 10.1128/JCM.43.2.745-749.2005.

Abstract

Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteremia / microbiology
  • Bacteremia / mortality*
  • Child, Preschool
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / pathogenicity
  • Enterobacteriaceae Infections / microbiology
  • Enterobacteriaceae Infections / mortality*
  • Escherichia coli / enzymology
  • Escherichia coli / pathogenicity
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Klebsiella pneumoniae / enzymology
  • Klebsiella pneumoniae / pathogenicity
  • Male
  • Salmonella enterica / classification
  • Salmonella enterica / enzymology
  • Salmonella enterica / pathogenicity
  • Tanzania / epidemiology
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • beta-lactamase SHV-12
  • beta-Lactamases