Although most equine wounds can be easily treated and heal without consequence, there are many that present special challenges. Skin grafts area valuable part of the veterinarian's armamentarium for treatment of complicated wounds, particularly limb wounds. Attention to preparation of the recipient site and proper aftercare are critical to successful grafting. With better understanding of equine wound and graft physiology and the promise foretold by advances in human skin grafting, the outcome of treatments of difficult equine wounds should continue to improve in the future.