Abstract
A new 4alpha-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Bursera / chemistry*
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Cell Line, Tumor
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Circular Dichroism
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Drug Screening Assays, Antitumor
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Humans
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Lignans / chemistry*
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Mexico
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Plant Extracts / chemistry
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Plant Stems / chemistry
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Tetrahydronaphthalenes / chemistry*
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Tetrahydronaphthalenes / isolation & purification
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Tetrahydronaphthalenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Lignans
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Plant Extracts
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Tetrahydronaphthalenes
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burseranin