Distribution of subclasses mefA and mefE of the mefA gene among clinical isolates of macrolide-resistant (M-phenotype) Streptococcus pneumoniae, viridans group streptococci, and Streptococcus pyogenes

Carmen Ardanuy; Fe Tubau; Josefina Liñares; María Angeles Domínguez; Román Pallarés; Rogelio Martín; Spanish Pneumococcal Infection Study Network (G03/103)

doi:10.1128/AAC.49.2.827-829.2005

Distribution of subclasses mefA and mefE of the mefA gene among clinical isolates of macrolide-resistant (M-phenotype) Streptococcus pneumoniae, viridans group streptococci, and Streptococcus pyogenes

Antimicrob Agents Chemother. 2005 Feb;49(2):827-9. doi: 10.1128/AAC.49.2.827-829.2005.

Authors

Carmen Ardanuy¹, Fe Tubau, Josefina Liñares, María Angeles Domínguez, Román Pallarés, Rogelio Martín; Spanish Pneumococcal Infection Study Network (G03/103)

Affiliation

¹ Servicio de Microbiologia. Hospital de Bellvitge, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. c.ardanuy@csub.scs.es

Abstract

The distribution of subclasses mefA and mefE of the mefA gene among 116 M-phenotype streptococci was as follows: pneumococci (38 strains had mefE and 4 mefA), viridans streptococci (49 mefE and 1 mefA), and Streptococcus pyogenes (24 mefA). Spain(9V)-3-14 and England(14)-9 clones of serotype 14 were dominant among pneumococci.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics*
Drug Resistance, Bacterial
England
France
Humans
Macrolides / pharmacology*
Membrane Proteins / genetics*
Phenotype
Serotyping
Spain
Streptococcal Infections / microbiology
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / genetics*
Streptococcus pyogenes / drug effects*
Streptococcus pyogenes / genetics*
Viridans Streptococci / drug effects*
Viridans Streptococci / genetics*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Macrolides
MefA protein, Streptococcus
MefE protein, Streptococcus pneumoniae
Membrane Proteins