Cytokines and endometriosis

Clin Exp Obstet Gynecol. 2004;31(4):269-70.

Abstract

Introduction: Abnormal expression of cytokines is considered to be involved in the pathogenesis of endometriosis.

Material and methods: In 63 women with various stages of endometriosis preoperative levels of cytokines, including IL-6, IL-8, BVEGF, b-FGF, of TNF RI and TNF RII were analysed employing ELISA tests (R&D kits).

Results: In the sera of endometriosis patients significantly augmented levels of IL-6 and of b-FGF were detected as well as a trend for elevated IL-8 levels.

Conclusion: Elevated serum levels of cytokines may show poor correspondence to the localized pathological process. Endometriosis would find a stricter reflection in cytokine levels in fluids or tissues of the pelvis minor.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cytokines / blood*
  • Endometriosis / metabolism*
  • Endometriosis / pathology
  • Endometriosis / surgery
  • Female
  • Humans
  • Middle Aged

Substances

  • Cytokines