Hantaviruses: immunology, treatment, and prevention

Viral Immunol. 2004;17(4):481-97. doi: 10.1089/vim.2004.17.481.

Abstract

Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antiviral Agents / therapeutic use
  • Drug Design
  • Hantavirus Infections* / drug therapy
  • Hantavirus Infections* / immunology
  • Hantavirus Infections* / prevention & control
  • Hantavirus Infections* / virology
  • Hantavirus Pulmonary Syndrome* / drug therapy
  • Hantavirus Pulmonary Syndrome* / immunology
  • Hantavirus Pulmonary Syndrome* / prevention & control
  • Hantavirus Pulmonary Syndrome* / virology
  • Hemorrhagic Fever with Renal Syndrome* / drug therapy
  • Hemorrhagic Fever with Renal Syndrome* / immunology
  • Hemorrhagic Fever with Renal Syndrome* / prevention & control
  • Hemorrhagic Fever with Renal Syndrome* / virology
  • Humans
  • Mice
  • Molecular Sequence Data
  • Orthohantavirus* / classification
  • Orthohantavirus* / immunology
  • Orthohantavirus* / pathogenicity
  • Viral Vaccines

Substances

  • Antiviral Agents
  • Viral Vaccines