Abstract
A gramicidin A derivative with a polyether linkage between both ethanolamine termini was synthesized and its ion channel properties were studied. The compound showed a duplication in the state of conductance for alkali cations in thick DOPC bilayer membranes, which is interpreted as the occurrence of twin-channels. In thinner DMPC membranes mono-channels were dominant. The influence of hydrophobic coupling on the mono channel/twin channel equilibrium is discussed.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Dimerization
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Dimyristoylphosphatidylcholine / chemistry*
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Electric Conductivity
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Gramicidin / chemistry*
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Hydrophobic and Hydrophilic Interactions
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Ion Channel Gating*
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Ion Channels / chemistry*
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Membrane Fluidity
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Membrane Lipids / chemistry*
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Membranes, Artificial
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Models, Chemical
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Models, Molecular
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Phosphatidylcholines / chemistry*
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Protein Conformation
Substances
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Ion Channels
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Membrane Lipids
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Membranes, Artificial
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Phosphatidylcholines
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Gramicidin
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1,2-oleoylphosphatidylcholine
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Dimyristoylphosphatidylcholine