Propylene glycol is essential in the LCModel basis set for pediatric 1H-MRS

J Comput Assist Tomogr. 2005 Jan-Feb;29(1):136-9. doi: 10.1097/01.rct.0000145860.13963.2f.

Abstract

Propylene glycol (PG) is an organic solvent used in a variety of parenterally injected pharmaceutical preparations. In this current study, we analyzed neonatal brains following routine MRS evaluation at 1.5 T, using the LCModel software, with and without the addition of PG to the analysis basis-set. We suggest including PG in the LCModel basis-set for neonatal brain H-MRS to improve the discrimination and quantification of lactate and inositol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / analysis
  • Basal Ganglia / metabolism
  • Brain / metabolism*
  • Choline / analysis
  • Creatine / analysis
  • Glutamic Acid / analysis
  • Glutamine / analysis
  • Humans
  • Infant, Newborn
  • Inositol / analysis
  • Lactic Acid / analysis
  • Magnetic Resonance Spectroscopy / methods*
  • Polyethylene Glycols / analysis*
  • Retrospective Studies
  • Software
  • Solvents / analysis*
  • Taurine / analysis

Substances

  • Solvents
  • Glutamine
  • Taurine
  • Aspartic Acid
  • Lactic Acid
  • Glutamic Acid
  • Polyethylene Glycols
  • Inositol
  • N-acetylaspartate
  • Creatine
  • Choline