Abstract
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bacterial Adhesion / genetics
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Bacterial Adhesion / physiology*
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Burkholderia pseudomallei / genetics
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Burkholderia pseudomallei / metabolism*
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Burkholderia pseudomallei / pathogenicity
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans / microbiology
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Cells, Cultured
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Epithelial Cells / metabolism
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Epithelial Cells / microbiology
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Fimbriae Proteins / metabolism*
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Fimbriae, Bacterial / genetics
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Fimbriae, Bacterial / metabolism*
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Humans
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Mice
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Time Factors