This study focuses on cranium development during puberty growth spurt in patients with complete unilateral cleft of the lip and palate (UCLPc) after use of various surgery methods. Next, this study focuses on cranium development differences between the genders in patients undergoing operations by the same method, as well as comparison of intracranial relations between impaired and healthy individuals. The work is based on longitudinal cephalometric measurement of X-ray films and it is interpreted by cluster analysis. It focuses mainly on mutual interrelations of linear dimensions (meaning longitudinal and vertical) with angular dimensions (characteristic of shape and position). Mutual relationships of linear characteristics were closer than its relationship with the angular characteristics and characteristics of shape and position were mutually closely related than with characteristics of the size. The development of the cranial shape in regards to the linear dimensions is influenced particularly by the depth of maxilla, the length of the ramus of the mandible, and the height of the upper face. The study confirms the least positive development of cranium in boys with a bone graft. Girls undergoing operations with the same technique have the advantage of earlier growth termination of most parts of the cranium, which makes it possible to maintain the results of the therapeutical compensation of the defect.