Microwave-assisted synthesis of novel thiazolocarbazoles and evaluation as potential anticancer agents. Part III

J Enzyme Inhib Med Chem. 2004 Dec;19(6):467-73. doi: 10.1080/14756360412331280491.

Abstract

Novel 6-substituted thiazolocarbazole derivatives have been synthesized under microwave irradiation via the corresponding imino-1,2,3-dithiazoles. In vitro antitumor potential of these polyheterocyclic compounds was evaluated. Among all the tested thiazolocarbazoles, compound 10 is the most effective in inhibiting cell growth.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / pharmacology
  • Antineoplastic Agents* / radiation effects
  • Carbazoles* / chemical synthesis
  • Carbazoles* / pharmacology
  • Carbazoles* / radiation effects
  • Cell Line
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • In Vitro Techniques
  • Microwaves*
  • Molecular Structure
  • Stereoisomerism
  • Structure-Activity Relationship
  • Thiazoles* / chemical synthesis
  • Thiazoles* / pharmacology
  • Thiazoles* / radiation effects

Substances

  • Antineoplastic Agents
  • Carbazoles
  • Thiazoles