Abstract
PTP1B is a ubiquitously expressed intracellular protein tyrosine phosphatase. Several lines of evidence support an important role for protein tyrosine phosphatase 1B(PTP1B) in metabolism, and specially in type 2 diabetes and obesity. Overexpression of PTP1B protein has been observed in insulin-resistant states associated with obesity. PTP1B is a negative regulator of insulin and leptin signaling, PTP1B inhibitors might be efficacious in the treatment of type 2 diabetes and obesity by increasing insulin and leptin sensitivity.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / enzymology*
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Diabetes Mellitus, Type 2 / genetics
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Enzyme Inhibitors / therapeutic use
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Gene Expression Regulation, Enzymologic / drug effects
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Humans
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Insulin / metabolism
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Leptin / metabolism
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Obesity / drug therapy
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Obesity / enzymology*
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Obesity / genetics
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / genetics
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism*
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Signal Transduction / drug effects
Substances
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Enzyme Inhibitors
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Insulin
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Leptin
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PTPN1 protein, human
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Protein Tyrosine Phosphatase, Non-Receptor Type 1