[Role of protein tyrosine phosphatase 1B in the type 2 diabetes and obesity]

Yi Chuan. 2004 Nov;26(6):941-6.
[Article in Chinese]

Abstract

PTP1B is a ubiquitously expressed intracellular protein tyrosine phosphatase. Several lines of evidence support an important role for protein tyrosine phosphatase 1B(PTP1B) in metabolism, and specially in type 2 diabetes and obesity. Overexpression of PTP1B protein has been observed in insulin-resistant states associated with obesity. PTP1B is a negative regulator of insulin and leptin signaling, PTP1B inhibitors might be efficacious in the treatment of type 2 diabetes and obesity by increasing insulin and leptin sensitivity.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / enzymology*
  • Diabetes Mellitus, Type 2 / genetics
  • Enzyme Inhibitors / therapeutic use
  • Gene Expression Regulation, Enzymologic / drug effects
  • Humans
  • Insulin / metabolism
  • Leptin / metabolism
  • Obesity / drug therapy
  • Obesity / enzymology*
  • Obesity / genetics
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / genetics
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism*
  • Signal Transduction / drug effects

Substances

  • Enzyme Inhibitors
  • Insulin
  • Leptin
  • PTPN1 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1