Evaluation of oligo(ethylene glycol) dimethacrylates effects on the properties of new biodegradable bone cement compositions

Macromol Biosci. 2005 Jan 14;5(1):64-9. doi: 10.1002/mabi.200400135.

Abstract

New injectable, in situ curable liquid formulations consisting of biodegradable aliphatic polyester, i.e., poly(3-allyloxy-1,2-propylene)succinate (PSAGE), methyl methacrylate (MMA), and hydrophilic oligo(ethylene glycol) dimethacrylates (OEGDMA) were investigated. The effect of MMA/OEGDMA ratio, OEGDMA molecular weight, i.e., the length of oligooxyethylene fragments, on the maximum curing temperature, setting time, compressive strength and modulus of the cured materials as well as their hydrophilicity were examined. The latter was characterized by determination of equilibrium water content and static water contact angle. The maximum temperature during crosslinking was found to decrease with increasing OEGDMA molecular weight and decreasing MMA/OEGDMA ratio. The setting time was affected strongly by the concentration of double bonds and was rapidly shortened with its increase. The compressive strength and compressive modulus values decreased with increasing OEGDMA molecular weight and decreasing MMA/OEGDMA ratio. Poly(3-allyloxy-1,2-propylene succinate).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Bone Cements / chemistry*
  • Dose-Response Relationship, Drug
  • Ethylene Glycol / chemistry
  • Methacrylates / chemistry*
  • Models, Chemical
  • Polymers / chemistry
  • Polypropylenes
  • Succinic Anhydrides / chemistry
  • Temperature
  • Time Factors
  • Water

Substances

  • Biocompatible Materials
  • Bone Cements
  • Methacrylates
  • Polymers
  • Polypropylenes
  • Succinic Anhydrides
  • Water
  • succinic anhydride
  • ethylene dimethacrylate
  • Ethylene Glycol