PTP1B inhibitors from Ardisia japonica

Yan-Fang Li; Li-Hong Hu; Feng-Chang Lou; Jia Li; Qiang Shen

doi:10.1080/10286020310001596033

PTP1B inhibitors from Ardisia japonica

J Asian Nat Prod Res. 2005 Feb;7(1):13-8. doi: 10.1080/10286020310001596033.

Authors

Yan-Fang Li¹, Li-Hong Hu, Feng-Chang Lou, Jia Li, Qiang Shen

Affiliation

¹ Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai, China.

PMID: 15621596
DOI: 10.1080/10286020310001596033

Abstract

In bioassay-directed isolation from the whole plant of Ardisia japonica, sixteen known compounds: chrysophanol (1), physcion (2), oleanolic acid (3), euscaphic acid (4), tormentic acid (5), quercetin (6), quercitrin (7), myricitrin (8), kaempferol 3-O-alpha-L-rhamnopyranoside (9), cyclamiretin A 3-O-alpha--rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->2)-[beta-D-glucopyranosyl(1-->4)]-alpha-L-arabinopyranoside (10), (7E)-9-hydroxymegastigma-4, 7-dien-3-on-9-O-beta-D-glucopyranoside (11), bergenin (12), norbergenin (13), rutin (14), kaempferol 3,7-O-alpha-L-dirhamnopyranoside (15), (-)-epigallacatechin 3-O-gallate (16) were obtained. Compounds 1-5, 9, 11 and 14-16 have not been reported previously from this plant. Among these isolates, 2, 3, 6 and 12 showed moderate bioactivity against PTP1B in vitro with IC50 values of 121.50, 23.90, 28.12 and 157 microM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ardisia / chemistry*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases