Characterization of In100, a new integron carrying a metallo-{beta}-lactamase and a carbenicillinase, from Pseudomonas aeruginosa

Antimicrob Agents Chemother. 2005 Jan;49(1):451-3. doi: 10.1128/AAC.49.1.451-453.2005.

Abstract

In100, a new integron carrying a carbapenemase gene (bla(VIM-2)) associated with a carbenicillinase (blaP1b) and aminoglycoside resistance genes (aacA4 and aadA2), was detected in a Pseudomonas aeruginosa clinical isolate. The particular gene cassette organization of In100 seems to reflect the evolution of antibiotic usage in therapeutics.

MeSH terms

  • Aminoglycosides / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Humans
  • Integrons / genetics*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Penicillinase / genetics*
  • Penicillinase / metabolism
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / enzymology
  • Pseudomonas aeruginosa / genetics
  • Sequence Analysis, DNA
  • beta-Lactam Resistance / genetics*
  • beta-Lactamases / genetics*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Penicillinase
  • beta-lactamase bla(vim-2)
  • beta-Lactamases

Associated data

  • GENBANK/AY560837