Aim: In the following study we evaluated the biological response of a new freely moldable bone substitute in an animal model.
Material and methods: Critically sized defects were created surgically in the lower jaw of ten adult minipigs. The drill defects were filled with hydroxyapatite collagen paste. After observation periods of 1, 3, 6, 12, and 18 months the mandibles were harvested without wound healing defects for histological evaluation of resorption and bone ingrowth with a sawing and grinding technique.
Results: The result of the remodeling process was a complete degradation of hydroxyapatite collagen implants after 12-18 months with reorganization of vital trabeculae oriented in a mature pattern.
Conclusion: The hydroxyapatite collagen cement works as an osteoconductor and shows signs of direct osseointegration and resorption.