Abstract
The authors present a case of obsessive-compulsive disorder (OCD) resistant to conventional treatments, which improved following nicotine augmentation administered as 4 mg chewing gum. The role of acetylcholine in the pathophysiology of OCD is not clear. The authors discuss the effect of nicotine on memory for actions.
MeSH terms
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Acetylcholine / physiology
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Adult
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Antidepressive Agents, Tricyclic / therapeutic use
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Clomipramine / therapeutic use
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Drug Resistance
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GABA Agents / therapeutic use
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Humans
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Male
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Nicotine / therapeutic use*
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Nicotinic Agonists / therapeutic use*
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Obsessive-Compulsive Disorder / drug therapy*
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Valproic Acid / therapeutic use
Substances
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Antidepressive Agents, Tricyclic
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GABA Agents
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Nicotinic Agonists
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Valproic Acid
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Nicotine
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Acetylcholine
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Clomipramine