Nicotine augmentation for refractory obsessive-compulsive disorder. A case report

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jan;29(1):157-9. doi: 10.1016/j.pnpbp.2004.08.011.

Abstract

The authors present a case of obsessive-compulsive disorder (OCD) resistant to conventional treatments, which improved following nicotine augmentation administered as 4 mg chewing gum. The role of acetylcholine in the pathophysiology of OCD is not clear. The authors discuss the effect of nicotine on memory for actions.

Publication types

  • Case Reports

MeSH terms

  • Acetylcholine / physiology
  • Adult
  • Antidepressive Agents, Tricyclic / therapeutic use
  • Clomipramine / therapeutic use
  • Drug Resistance
  • GABA Agents / therapeutic use
  • Humans
  • Male
  • Nicotine / therapeutic use*
  • Nicotinic Agonists / therapeutic use*
  • Obsessive-Compulsive Disorder / drug therapy*
  • Valproic Acid / therapeutic use

Substances

  • Antidepressive Agents, Tricyclic
  • GABA Agents
  • Nicotinic Agonists
  • Valproic Acid
  • Nicotine
  • Acetylcholine
  • Clomipramine