Abstract
Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8(+) T cells. This pathway is important for the development of CD8(+) cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8(+) T cell activation and implementing novel vaccine strategies is considered.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigen Presentation*
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CD8-Positive T-Lymphocytes / immunology
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Cell Differentiation
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Cytosol / immunology
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Dendritic Cells / cytology
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Dendritic Cells / immunology
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Histocompatibility Antigens Class I / metabolism
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Histocompatibility Antigens Class II / metabolism
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Humans
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Ligands
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Membrane Glycoproteins / immunology*
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Mice
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Receptors, Cell Surface / immunology*
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Toll-Like Receptors
Substances
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II
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Ligands
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Membrane Glycoproteins
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Receptors, Cell Surface
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Toll-Like Receptors