Unified perspective on proteins: a physics approach

Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Oct;70(4 Pt 1):041905. doi: 10.1103/PhysRevE.70.041905. Epub 2004 Oct 27.

Abstract

We study a physical system which, while devoid of the complexity one usually associates with proteins, nevertheless displays a remarkable array of proteinlike properties. The constructive hypothesis that this striking resemblance is not accidental not only leads to a unified framework for understanding protein folding, amyloid formation, and protein interactions but also has implications for natural selection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Binding Sites
  • Computer Simulation
  • Models, Chemical*
  • Models, Molecular*
  • Multiprotein Complexes / analysis
  • Multiprotein Complexes / chemistry*
  • Physics / methods
  • Protein Binding
  • Protein Conformation
  • Protein Folding
  • Proteins / analysis
  • Proteins / chemistry*

Substances

  • Multiprotein Complexes
  • Proteins