Abstract
Association between RNA and DNA strands to form RNA-DNA heteroduplex is important in many biological processes such as transcription, DNA replication and reverse transcription. Herein, binding affinities of a 17-mer BIV Tat peptide is compared with TAR DNA duplex, TAR RNA-DNA heteroduplex and TAR RNA duplex. It was observed that binding affinities of Tat peptide is comparable against DNA-RNA heteroduplex and RNA duplex, whereas DNA duplex binding is decidedly poor.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Circular Dichroism
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DNA, Viral / chemistry
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DNA, Viral / genetics
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Gene Products, tat / chemistry
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Gene Products, tat / genetics
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Gene Products, tat / metabolism*
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Immunodeficiency Virus, Bovine / genetics
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Immunodeficiency Virus, Bovine / metabolism*
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Nucleic Acid Heteroduplexes*
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Protein Binding
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RNA, Viral / chemistry
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RNA, Viral / genetics
Substances
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DNA, Viral
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Gene Products, tat
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Nucleic Acid Heteroduplexes
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RNA, Viral