We assessed the value of computed tomography (CT) and anthropometric skinfold analysis for evaluating subcutaneous facial fat in human immunodeficiency virus-infected patients. Patients with facial lipoatrophy had smaller areas of facial adipose tissue, lower ratios of adipose tissue area to total tissue area of the face, and lower malar skinfold values, compared with patients without facial wasting. CT may be a useful technique to diagnose and monitor facial lipoatrophy.