Abstract
Streptococcus mutans F-ATPase, the major component of the acid-adaptive response of the organism, is transcriptionally upregulated at low pH. Fusions of the F-ATPase promoter to chloramphenicol acetyltransferase indicated that pH-dependent expression is still observed with a short promoter that contains a domain conserved between streptococcal ATPase operons.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Proton-Translocating ATPases / genetics
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Bacterial Proton-Translocating ATPases / metabolism*
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Base Sequence
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Gene Expression Regulation, Bacterial*
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Humans
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Hydrogen-Ion Concentration
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Molecular Sequence Data
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Operon*
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Promoter Regions, Genetic*
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Streptococcus mutans / enzymology*
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Streptococcus mutans / genetics
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Streptococcus mutans / growth & development
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Transcription, Genetic*
Substances
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Bacterial Proton-Translocating ATPases