Abstract
We have examined the effect of hypoxanthine on adenosine transport and [3H] NBTI binding in peripheral blood lymphocytes (PBL) cultures. Pre-incubation with hypoxanthine originates a dose dependent decrease of adenosine transport and [3H] NBTI binding sites in PBL.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenosine / blood*
-
Adenosine / metabolism
-
Binding Sites
-
Biological Transport
-
Cyclic AMP / metabolism*
-
Dose-Response Relationship, Drug
-
Humans
-
Hypoxanthine / pharmacology*
-
Lesch-Nyhan Syndrome / blood*
-
Lesch-Nyhan Syndrome / metabolism
-
Lymphocytes / drug effects
-
Lymphocytes / metabolism*
-
Time Factors
Substances
-
Hypoxanthine
-
Cyclic AMP
-
Adenosine