Effects of hypoxanthine on adenosine transport in human lymphocytes. Implications in the pathogenesis of Lesch-Nyhan syndrome

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1177-9. doi: 10.1081/NCN-200027444.

Abstract

We have examined the effect of hypoxanthine on adenosine transport and [3H] NBTI binding in peripheral blood lymphocytes (PBL) cultures. Pre-incubation with hypoxanthine originates a dose dependent decrease of adenosine transport and [3H] NBTI binding sites in PBL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / blood*
  • Adenosine / metabolism
  • Binding Sites
  • Biological Transport
  • Cyclic AMP / metabolism*
  • Dose-Response Relationship, Drug
  • Humans
  • Hypoxanthine / pharmacology*
  • Lesch-Nyhan Syndrome / blood*
  • Lesch-Nyhan Syndrome / metabolism
  • Lymphocytes / drug effects
  • Lymphocytes / metabolism*
  • Time Factors

Substances

  • Hypoxanthine
  • Cyclic AMP
  • Adenosine