New sesquiterpenes from Pluchea arabica

J Nat Prod. 2004 Nov;67(11):1925-8. doi: 10.1021/np040054c.

Abstract

Two new sesquiterpenes, godotol A (1) and godotol B (2), were isolated from Pluchea arabica. Their structures were determined by analysis of NMR data. The absolute configurations of 1 and 2 were established by Mosher ester methodology. The godotols displayed weak activity against bacteria and the brine shrimp larvae. They were also inactive in the DPPH antioxidant assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Artemia / drug effects
  • Asteraceae / chemistry*
  • Biphenyl Compounds
  • Candida albicans / drug effects
  • Escherichia coli / drug effects
  • Klebsiella pneumoniae / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oman
  • Picrates / pharmacology
  • Plants, Medicinal / chemistry*
  • Pseudomonas aeruginosa / drug effects
  • Salmonella arizonae / drug effects
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Staphylococcus aureus / drug effects

Substances

  • Biphenyl Compounds
  • Picrates
  • Sesquiterpenes
  • godotol A
  • godotol B
  • 1,1-diphenyl-2-picrylhydrazyl