Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces

Mark A Skidmore; Susannah J Patey; Nguyen T K Thanh; David G Fernig; Jeremy E Turnbull; Edwin A Yates

doi:10.1039/b411726c

Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces

Chem Commun (Camb). 2004 Dec 7:(23):2700-1. doi: 10.1039/b411726c. Epub 2004 Oct 11.

Authors

Mark A Skidmore¹, Susannah J Patey, Nguyen T K Thanh, David G Fernig, Jeremy E Turnbull, Edwin A Yates

Affiliation

¹ School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK.

PMID: 15568074
DOI: 10.1039/b411726c

Abstract

Glycosaminoglycan oligosaccharides have been attached to thiol-derivatised gold surfaces, via the formation of mercury-sugar adducts at the non-reducing end, representing a new method of generating versatile glycoconjugates incorporating this class of biologically and medically important carbohydrate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fibroblast Growth Factor 2 / chemistry
Glycosaminoglycans / chemistry*
Gold / chemistry*
Mercury Compounds / chemistry
Sulfhydryl Compounds

Substances

Glycosaminoglycans
Mercury Compounds
Sulfhydryl Compounds
Fibroblast Growth Factor 2
Gold