Aging muscle and joint changes can have a tremendous impact on the functionality of elderly people with and without disabilities. Studies in animal models have shown some potentially beneficial interventions (eg, gene therapy). Further research is needed to ascertain their benefits in humans. A better understanding of mechanisms by which skeletal muscle and joint changes take place in a geriatric population will be helpful to find reasonable ways to prevent age-related change and improve disability. Although some agents have been reported to have significant positive effects, further studies are needed to determine long-term side effects. More information is needed with respect to the changes in muscles and joints in various disabilities.