Inhibitory activity of cyanidin-3-rutinoside on alpha-glucosidase

J Enzyme Inhib Med Chem. 2004 Aug;19(4):313-6. doi: 10.1080/14756360409162443.

Abstract

Cyanidin-3-rutinoside, a natural anthocyanin, inhibited alpha-glucosidase from baker's yeast in dose-responsive manner. The IC50 value was 19.7 microM +/- 0.24 microM, compared with the IC50 value of voglibose (IC50 = 23.4 +/- 0.30 microM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeast alpha-glucosidase with a Ki value in the range of 1.31-1.56 x 10(-5)M. These results indicated that cyanidin-3-rutinoside could be classed as a new alpha-glucosidase inhibitor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthocyanins / chemical synthesis
  • Anthocyanins / chemistry
  • Anthocyanins / pharmacology*
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology*
  • Glycoside Hydrolase Inhibitors*
  • Inositol / analogs & derivatives*
  • Inositol / pharmacology
  • Kinetics
  • Molecular Structure
  • Yeasts / enzymology
  • alpha-Glucosidases / chemistry

Substances

  • Anthocyanins
  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Inositol
  • alpha-Glucosidases
  • cyanidin 3-rutinoside
  • voglibose