We report two cases of spinal cord compression due to vertebral hemangioma in the first patient and myeloma in the other. Vertebroplasty was performed in both patients, combined with surgery for the first and radiotherapy for the second. Postprocedural pain decreased within 24 hours. Indications for percutaneous vertebroplasty are limited to aggressive vertebral hemangiomas, malignant spinal tumors including metastasis, multiple myeloma and solitary bone plasmocytoma. Vertebroplasty consolidates the vertebral body and reduces the risk of hemorrhage. It allows provides a rapid analgesic effect, radicullomedullary decompression associated with neurosurgery, spinal stabilization and can restrict progression of vascular malformations or tumors. Incidents and complications appear to be rare.